Histamine intolerance manifests in up to 3% of the population (80% in middle-aged women), but how much is unidentified or unreported considering the rapidly increasing number of those who suffer?
Since histamine is involved in inflammatory and immune response as well as regulating physiological function in the gut and acting as a neurotransmitter, increased levels can cause a myriad of unwanted and often debilitating symptoms. To make matters worse, those with genomic expression affecting either direct histamine enzymes or related methylation function have more severe reactions. Patients struggle with the conventional recommendation of antihistamine medication with unwanted side-effects and restrictive histamine avoidance diets. They want more answers!